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lcmodel analysis program  (Provencher Inc)

 
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    Provencher Inc lcmodel analysis program
    Lcmodel Analysis Program, supplied by Provencher Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lcmodel analysis program/product/Provencher Inc
    Average 90 stars, based on 1 article reviews
    lcmodel analysis program - by Bioz Stars, 2026-05
    90/100 stars

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    lcmodel (version 6.0-1) analysis program  (Provencher Inc)
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    Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during <t>LCModel</t> analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.
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    Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

    Journal: Neuropsychopharmacology

    Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

    doi: 10.1038/npp.2012.101

    Figure Lengend Snippet: Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

    Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

    Techniques: Serial Time-encoded Amplified Microscopy

    Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

    Journal: Neuropsychopharmacology

    Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

    doi: 10.1038/npp.2012.101

    Figure Lengend Snippet: Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

    Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

    Techniques: Serial Time-encoded Amplified Microscopy, Spectroscopy, Sequencing